Premium
Histologic and histomorphometric evaluation of the bone regeneration following cortical bone repositioning in a rabbit mandible
Author(s) -
Martinezde la Cruz Gerardo,
Yamauchi Kensuke,
Odajima Kenji,
Kataoka Yoshihiro,
Nogami Shinnosuke,
Takahashi Tetsu
Publication year - 2019
Publication title -
clinical implant dentistry and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 85
eISSN - 1708-8208
pISSN - 1523-0899
DOI - 10.1111/cid.12777
Subject(s) - mandible (arthropod mouthpart) , cortical bone , medicine , dentistry , bone formation , histology , bone healing , anatomy , pathology , biology , botany , genus
Background Although bone graft (BG) is the gold standard for bone augmentation, its use is hampered by donor site morbidity and limited quantity. Purpose To evaluate the capabilities of bone formation by cortical bone repositioning (CBR) as the healing response following grafting of autogenous bone block without filling biomaterial at the gap between gap and recipient. Materials and Methods Twelve Japanese White rabbits were divided into three groups (postoperative 2, 5, and 8 weeks). A cortical block was freed from the mandibular body, half of the block was positioned and fixed overlapped the original bone surface beside the defect and the other half remained only elevated above the defect. Three areas were decided for the evaluation; BG, CBR, and defect (D) area. Areas were evaluated by micro‐CT, histology, and histomorphometric analysis. Results There is no statistical difference between BG and CBR by evaluating distance and area in histomorphometrical analysis ( P < .05). D area showed statistical decrease compared with BG and CBR at week 2. Histologically, new bone was evident at week 2, mature bone was observed in all three areas at week 8, D area disappeared and fused completely with the elevated bone block. Conclusion CBR has potential for bone augmentation as BG induced from its own regenerative ability of healing process.