Premium
A thermosensitive chitosan‐based hydrogel for sealing and lubricating purposes in dental implant system
Author(s) -
Cao Xiaoxiao,
Cai Xinjie,
Chen Ruiying,
Zhang Huimei,
Jiang Tao,
Wang Yining
Publication year - 2019
Publication title -
clinical implant dentistry and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 85
eISSN - 1708-8208
pISSN - 1523-0899
DOI - 10.1111/cid.12738
Subject(s) - chitosan , cytotoxicity , materials science , implant , biomedical engineering , dental implant , nuclear chemistry , fourier transform infrared spectroscopy , composite material , chemistry , chemical engineering , in vitro , surgery , organic chemistry , medicine , biochemistry , engineering
Background Mechanical and biological complications associated with implant systems happen frequently in the clinic. Purpose To develop a chitosan (CS)‐based thermosensitive hydrogel for sealing and lubricating purposes in dental implant system. Materials and Methods In this study, a thermosensitive hydrogel made up of CS, β‐glycerophosphate pentahydrate (β‐GP), and povidone‐iodine (PVP‐I), called CS/β‐GP/PVP‐I thermosensitive hydrogel, was fabricated. Three experimental groups with different volume ratios of CS to β‐GP were prepared, namely 16/4, 13/7, and 10/10 groups. The surface topography of the different groups and their physicochemical characteristics were examined by SEM, FTIR, and X‐ray diffraction analysis. The cytotoxicity of the hydrogel was examined by CCK‐8 test. In vitro antibacterial efficiency was analyzed by the spread plate method. Sealing ability was detected by incubating two‐piece implants in Escherichia coli suspension. Lubricating ability of the hydrogel was evaluated by the removal torque test with a calibrated digital torque meter. Results The CS/β‐GP/PVP‐I thermosensitive hydrogel was fabricated and showed a highly porous structure under SEM. An in vitro cytotoxicity test demonstrated that 13/7 group displayed no cytotoxicity. Furthermore, all three groups showed obviously antibacterial effects. In the sealing ability test, 16/4 group showed the best sealing ability. The removal torque of 16/4 group and 13/7 group was significantly greater than control group. Conclusions Based on our findings, it could be concluded that the thermosensitive and antibacterial CS/β‐GP/PVP‐I hydrogel with sealing and lubricating ability was successfully prepared. The hydrogel had better sealing and lubricating effects when the volume ratio of CS to β‐GP was 16/4.