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Identifying a combined biomarker for bisphosphonate‐related osteonecrosis of the jaw
Author(s) -
Kim KiYeol,
Zhang Xianglan,
Cha InHo
Publication year - 2018
Publication title -
clinical implant dentistry and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 85
eISSN - 1708-8208
pISSN - 1523-0899
DOI - 10.1111/cid.12569
Subject(s) - osteonecrosis of the jaw , medicine , bisphosphonate , biomarker , microarray analysis techniques , bisphosphonate associated osteonecrosis of the jaw , bioinformatics , gene , gene expression , oncology , osteoporosis , biology , genetics
Abstract Background For this study, the aim was to identify combined biomarkers associated with bisphosphonate‐related osteonecrosis of the jaw (BRONJ). Materials and Methods Microarray data for GSE7116 were downloaded from the Gene Expression Omnibus database, which contains 26 samples, including without ONJ, and 5 healthy volunteers. The combined biomarkers were identified using principal component analysis, and the pathway enrichment analyses were performed using the DAVID online tool. Results Two hundred differently expressed genes between groups were detected according to the significances. From functional annotation, Y‐box binding protein 1 and heterogeneous nuclear ribonucleoprotein C were found to be included in the most significant 10 pathways. Ten combined gene sets were identified that were effective in classifying multiple myeloma (MM) with ONJ and MM without ONJ. Conclusion Identifying combined gene expression profiles is expected to contribute to more personalized management of BRONJ and to improve existing therapies, and it will be helpful in finding new therapies by identifying more predictive biomarkers.