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L actotransferrin Gene ( LTF ) Polymorphisms and Dental Implant Loss: A Case‐Control Association Study
Author(s) -
Doetzer Andrea Duarte,
Schlipf Nina,
AlvimPereira Fabiano,
AlvimPereira Claudia Cristina,
Werneck Renata,
Riess Olaf,
Bauer Peter,
Trevilatto Paula Cristina
Publication year - 2015
Publication title -
clinical implant dentistry and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 85
eISSN - 1708-8208
pISSN - 1523-0899
DOI - 10.1111/cid.12284
Subject(s) - edentulism , osseointegration , implant , tooth loss , single nucleotide polymorphism , medicine , dentistry , dental implant , population , gene , biology , genetics , genotype , oral health , surgery , environmental health
Background Dental implants have been widely used to replace missing teeth, accomplishing aesthetics and function. Due to its large use worldwide, the small percentage of implant loss becomes significant in number of cases. L actotransferrin ( LTF ) is a pleiotropic protein, expressed in various body tissues and fluids, which modulates the host immune‐inflammatory response and bone metabolism, and might be involved in dental implant osseointegration. Recently, a few studies have been investigating genetic aspects underlying dental implant failure. Purpose This case‐control study aimed to investigate the association of genetic markers (tag SNPs ) in LTF gene and clinical parameters with dental implant loss. Material and Methods 278 patients, both sexes, mean age 51 years old, divided into 184 without and 94 with implant loss, were genotyped for sixteen tag SNPs , representative of the whole LTF gene. Also, clinical oral and systemic parameters were analyzed. U nivariate and M ultivariate L ogistic R egression model were used to analyze the results ( p < .05). Results No association was found between the tag SNPs and implant loss in the study population. Clinical association was found with medical treatment, hormonal reposition, edentulism, number of placed implants, plaque, calculus, and mobility. Conclusion Clinical variables, but not LTF gene polymorphisms, were associated with implant loss.