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The Role of Chlorhexidine on Endotoxin Penetration to the Implant‐Abutment Interface ( IAI )
Author(s) -
Koutouzis Theofilos,
Gadalla Hana,
Kettler Zachary,
Elbarasi Amelsaad,
hoff Jörg
Publication year - 2015
Publication title -
clinical implant dentistry and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 85
eISSN - 1708-8208
pISSN - 1523-0899
DOI - 10.1111/cid.12158
Subject(s) - chlorhexidine , implant , saline , medicine , dentistry , penetration (warfare) , surgery , anesthesia , mathematics , operations research
Purpose The aim of this study is to assess the risk of endotoxin penetration to the implant‐abutment interface ( IAI ) of implants with Morse‐taper connection and the effect of chlorhexidine in the prevention of such penetration. Materials and Methods Thirty implants with M orse‐taper connection were divided into three groups ( n = 10/group) based on type of inoculation of the internal aspect of the implant. Implants in G roup 1 were inoculated with 1 μl E scherichia coli for 24 hours; supernatant was removed and 0.5 μl of sterile saline was added. Implants in G roup 2 were inoculated with 1 μl E . coli for 24 hours; supernatant was removed and 0.5 μl 0.2% chlorhexidine solution was added. Implants in G roup 3 were inoculated with 0.5 μl of sterile saline and served as controls. Following inoculation procedures, implants were connected to standard abutments, immersed in sterile culture media, and loaded with 200,000 cycles of 160 N in a wear simulator. Samples were collected from the supernatant solution of each implant for endotoxin identification at the beginning of the loading cycle ( T 0) and following 9 hours ( T 9), 18 hours ( T 18), 27 hours ( T 27), 36 hours ( T 36), 45 hours ( T 45), and 54 hours ( T 54). Results For G roup 1 and G roup 2, there were statistically significant differences between the endotoxin concentration at T 0 and the endotoxin concentration at the subsequent sampling points ( p < .05 K ruskal– W allis with B onferoni corrections for intragroup comparisons). There were no statistically significant differences between G roup 1 and G roup 2 at all sampling points. Conclusions This study indicates that bacterial endotoxin can penetrate the IAI of implants with M orse‐taper connection, and 0.2% chlorhexidine solution had no significant effect on that penetration.