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Time Interval after Radiotherapy and Dental Implant Failure: Systematic Review of Observational Studies and Meta‐Analysis
Author(s) -
Claudy Matheus Piardi,
Miguens Sergio Augusto Quevedo,
Celeste Roger Keller,
Camara Parente Raphael,
Hernandez Pedro Antonio González,
Silva Aurelício Novaes
Publication year - 2015
Publication title -
clinical implant dentistry and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 85
eISSN - 1708-8208
pISSN - 1523-0899
DOI - 10.1111/cid.12096
Subject(s) - medicine , meta analysis , observational study , confidence interval , relative risk , dentistry , implant failure , dental implant , randomized controlled trial , medline , radiation therapy , publication bias , implant , surgery , political science , law
Background Typically, dental implants are placed in irradiated bone after a delay that exceeds 6 months, but it is not known whether longer delays are beneficial. Purpose The purpose of the study is to review the literature comparing the failure rate of dental implants placed in irradiated bone between 6 and 12 months and after 12 months from the cessation of radiotherapy. Materials and Methods Four electronic databases were searched for articles published until F ebruary 2013 without language restriction: L ilacs, M edline, S copus, and the C ochrane C entral R egister of C ontrolled T rials. Two reviewers independently assessed the eligibility criteria and extracted data. Fixed effect meta‐analysis was performed. Results Overall, 3,749 observational studies were identified. After the screening of titles and abstracts, 236 publications were selected, and 10 were included in the final analysis. The pooled relative risk ( RR ) of failure was RR pooled = 1.34 (95% confidence interval [ CI ]: 1.01–1.79), higher in individuals who had dental implants installed between 6 and 12 months after receiving radiotherapy. I 2 indicated nearly 21% heterogeneity ( p = .25). E gger's test indicated no evidence of publication bias ( p = .62); however, the removal of one study significantly affected the overall RR ( RR pooled = 1.08, 95% CI : 0.77–1.52). Conclusions Placing implants in bone within a period shorter than 12 months after radiotherapy may result in a higher risk of failure; however, additional evidence from clinical trials is needed to verify this risk.