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Effects of Chronic Stress and Alendronate Therapy on the Osseointegration of Titanium Implants
Author(s) -
Conte Neto Nicolau,
Andrade Cleverton Roberto,
Spolidorio Luis Carlos,
Planeta Cleópatra da Silva,
Cruz Fábio Cardoso,
Souza Bastos Alliny,
Marcantonio Elcio
Publication year - 2014
Publication title -
clinical implant dentistry and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 85
eISSN - 1708-8208
pISSN - 1523-0899
DOI - 10.1111/cid.12046
Subject(s) - osseointegration , implant , medicine , saline , dentistry , alkaline phosphatase , bone remodeling , urology , surgery , chemistry , enzyme , biochemistry
Abstract Purposes The purposes of this study were to evaluate the influence of chronic stress ( CS ) on implant osseointegration and also to analyze whether alendronate ( ALN ) therapy could prevent these eventual stress‐negative effects. Materials and Methods Adult male H oltzmann rats were assigned to one of the four experimental groups: AL ( ALN ; 1 mg/kg/week; n = 12), ALS ( ALN + CS ; 1 mg/kg/week; n = 12), CTL (sterile physiological saline; n = 12), or CTLS (sterile physiological saline + CS ; n = 12). After 58 days of drug therapy, the ALS and CTLS groups were exposed to CS , and 2 days later all animals underwent tibial implant installation. The animals were euthanized 28 days following the operative surgical procedure. Results It was observed that the CTLS group presented an impairment of bone metabolism represented by lowest levels of bone‐specific alkaline phosphatase and bone area fraction occupancy values. Furthermore, these animals presented a higher proportion of empty osteocytic lacunae. In contrast, the ALN therapy showed increased osseointegration and torque value parameters, regardless of stress exposition. Conclusions Analysis of the data presented suggests that CS partially impairs the osseointegration of tibial implants and that ALN therapy is able to prevent these negative effects.