Premium
Accelerated and Enhanced Bone Formation on Novel Simvastatin‐Loaded Porous Titanium Oxide Surfaces
Author(s) -
Nyan Myat,
Hao Jia,
Miyahara Takayuki,
Noritake Kanako,
Rodriguez Reena,
Kasugai Shohei
Publication year - 2014
Publication title -
clinical implant dentistry and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 85
eISSN - 1708-8208
pISSN - 1523-0899
DOI - 10.1111/cid.12045
Subject(s) - osseointegration , simvastatin , titanium , apposition , implant , dentistry , dental implant , biomedical engineering , materials science , chemistry , medicine , surgery , metallurgy , anatomy
Background With increasing application of dental implants in poor‐quality bones, the need for implant surfaces ensuring accelerated osseointegration and enhanced peri‐implant bone regeneration is increased. Purpose A study was performed to evaluate the osseointegration and bone formation on novel simvastatin‐loaded porous titanium oxide surface. Materials and Methods Titanium screws were treated by micro‐arc oxidation to form porous oxide surface and 25 or 50 μg of simvastatin was loaded. The nontreated control, micro‐arc oxidized, and simvastatin‐loaded titanium screws were surgically implanted into the proximal tibia of 16‐week‐old male W istar rats ( n = 36). Peri‐implant bone volume, bone‐implant contact, and mineral apposition rates were measured at 2 and 4 weeks. Data were analyzed by one‐way analysis of variance followed by T ukey's post hoc test. Results New bone was formed directly on the implant surface in the bone marrow cavity in simvastatin‐loaded groups since 2 weeks. Bone‐implant contact values were significantly higher in simvastatin‐loaded groups than control and micro‐arc oxidized groups at both time points ( p < .05). Peri‐implant bone volume and mineral apposition rate of simvastatin‐loaded groups were significantly higher than control and micro‐arc oxidized groups at 2 weeks ( p < .05). Conclusions These data suggested that simvastatin‐loaded porous titanium oxide surface provides faster osseointegration and peri‐implant bone formation and it would be potentially applicable in poor‐quality bones.