In Vivo and In Vitro Studies of Epithelial Cell Behavior around Titanium Implants with Machined and Rough Surfaces | Zendy

Atsuta Ikiru | Zendy; Ayukawa Yasunori | Zendy; Furuhashi Akihiro | Zendy; Ogino Yoichiro | Zendy; Moriyama Yasuko | Zendy; Tsukiyama Yoshihiro | Zendy; Koyano Kiyoshi | Zendy

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In Vivo and In Vitro Studies of Epithelial Cell Behavior around Titanium Implants with Machined and Rough Surfaces

Author(s) -

Atsuta Ikiru,

Ayukawa Yasunori,

Furuhashi Akihiro,

Ogino Yoichiro,

Moriyama Yasuko,

Tsukiyama Yoshihiro,

Koyano Kiyoshi

Publication year - 2014

Publication title -

clinical implant dentistry and related research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.338

H-Index - 85

eISSN - 1708-8208

pISSN - 1523-0899

DOI - 10.1111/cid.12043

Subject(s) - implant , epithelium , in vivo , wound healing , molar , dentistry , dental implant , adhesion , titanium , junctional epithelium , materials science , osseointegration , chemistry , medicine , biology , pathology , surgery , composite material , microbiology and biotechnology , metallurgy

Background The surface roughness of a dental implant affects the epithelial wound healing process and may significantly enhance implant prognosis. Purpose We explored the influence of surface roughness on peri‐implant epithelium ( PIE ) sealing and down‐growth by comparing machine‐surfaced ( M s) and rough‐surfaced ( R s) implants. Materials and Methods (1) Maxillary first molars were extracted from rats and replaced with M s or R s implants. (2) We also compared changes in the morphology of cultured rat oral epithelial cells ( OECs ) grown on M s or R s titanium ( T i) plates. Results (1) After 4 weeks, the PIE around M s and R s implants showed a similar structure to junctional epithelium ( JE ). At 16 weeks, R s implants appeared to form a weak epithelial seal at the tissue‐implant interface and exhibited markedly less PIE down‐growth than M s implants but was deeper than that observed in natural teeth. (2) We observed less expression of adhesion proteins in OECs cultured on R s plates than in cells grown on M s plates. Additionally, cell adherence, migration, and proliferation on R s plates were lower, whereas apoptosis was reduced on M s plates. Conclusion M s implants are a better choice for integration with an epithelial wound healing process.

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