Premium
In Vivo Evaluation of a Novel Implant Coating Agent: Laminin‐1
Author(s) -
Bougas Kostas,
Jimbo Ryo,
Vandeweghe Stefan,
Tovar Nick,
Baldassarri Marta,
Alenezi Ali,
Janal Malvin,
Coelho Paulo G.,
Wennerberg Ann
Publication year - 2014
Publication title -
clinical implant dentistry and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 85
eISSN - 1708-8208
pISSN - 1523-0899
DOI - 10.1111/cid.12037
Subject(s) - osseointegration , nanoindentation , in vivo , implant , laminin , biomedical engineering , coating , materials science , dentistry , medicine , chemistry , surgery , composite material , biology , extracellular matrix , biochemistry , microbiology and biotechnology
Purpose The aim of this study was to assess the effect of implant coating with laminin‐1 on the early stages of osseointegration in vivo. Materials and Methods Turned titanium implants were coated with the osteoprogenitor‐stimulating protein, laminin‐1 ( TL ). Their osteogenic performance was assessed with removal torque, histomorphometry, and nanoindentation in a rabbit model after 2 and 4 weeks. The performance of the test implants was compared with turned control implants ( T ), alkali‐ and heat‐treated implants ( AH ), and AH implants coated with laminin‐1. Results After 2 weeks, TL demonstrated significantly higher removal torque as compared with T and equivalent to AH . Bone area was significantly higher for the test surface after 4 weeks, while no significant changes were detected on the micromechanical properties of the surrounding bone. Conclusions Within the limitations of this study, our results suggest a great potential for laminin‐1 as a coating agent. A turned implant surface coated with laminin‐1 could enhance osseointegration comparable with a bioactive implant surface while keeping the surface smooth.