Premium
New insight into the role of substance P/neurokinin‐1 receptor system in breast cancer progression and its crosstalk with microRNAs
Author(s) -
Ebrahimi Safieh,
Javid Hosein,
Alaei Amin,
Hashemy Seyed Isaac
Publication year - 2020
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/cge.13750
Subject(s) - crosstalk , biology , microrna , signal transduction , carcinogenesis , epigenetics , angiogenesis , metastasis , breast cancer , receptor , cancer research , tachykinin receptor 1 , substance p , microbiology and biotechnology , cancer , neuropeptide , gene , genetics , physics , optics
Abstract The neuropeptide substance P (SP) triggers a variety of tumor‐promoting signaling pathways through the activation of neurokinin‐1receptor (NK1R), a class of neurokinin G protein‐coupled receptors superfamily. Recent researches in our and other laboratories have shown the overexpression of both SP and NK1R in breast cancer (BC) patients. SP/NK1R signaling is strongly implicated in the pathogenesis of BC through affecting cell proliferation, migration, metastasis, angiogenesis, and resistance. Therefore, SP/NK1R signaling responses must be rigorously regulated; otherwise, they would contribute to a more aggressive BC phenotype. Recently, microRNAs (miRNAs) as a specific class of epigenetic regulators have been shown to regulate NK1R and thus, controlling SP/NK1R signaling responses in BC. This review summarizes the current knowledge of the role of SP/NK1R signaling and its therapeutic potentials in BC. We also provide an overview regarding the effects of miRNA‐mediated NK1R regulatory mechanisms in controlling BC tumorigenesis to gain a clearer view and thus better management of cancer.