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Uptake of polygenic risk information among women at increased risk of breast cancer
Author(s) -
Yanes Tatiane,
Meiser Bettina,
Kaur Rajneesh,
ScheepersJoynt Maatje,
McInerny Simone,
Taylor Shelby,
BarlowStewart Kristine,
Antill Yoland,
Salmon Lucinda,
Smyth Courtney,
Young MaryAnne,
James Paul A.
Publication year - 2020
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/cge.13687
Subject(s) - breast cancer , medicine , logistic regression , odds ratio , polygenic risk score , cancer , odds , oncology , demography , biology , single nucleotide polymorphism , genetics , genotype , sociology , gene
Polygenic risk scores (PRSs) are increasingly being implemented to assess breast cancer risk. This study aimed to assess and determine factors associated with uptake of PRS among women at increased risk of breast cancer for whom genetic testing to date had been uninformative. Participants were recruited from the Variants in Practice study from which breast cancer PRS had been calculated. Four hundred women were notified by letter of the availability of their PRS and invited to complete a self‐administered survey comprising several validated scales. Considering non‐participants, uptake of PRS was between 61.8% and 42.1%. Multivariate logistic regression identified that women were more likely to receive their PRS if they reported greater benefits (odds ratio [OR] = 1.17, P = .011) and fewer barriers to receiving their PRS (OR = 0.80, P = .007), had completed higher level education (OR = 3.32, P = .004), and did not have daughters (0.29, P = .006). Uptake of breast cancer PRS varied according to several testing‐ and patient‐related factors. Knowledge of these factors will facilitate the implementation of polygenic testing in clinical practice and support informed decision making by patients.