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The genetic pathogenesis, diagnosis and therapeutic insight of rheumatoid arthritis
Author(s) -
Zamanpoor Mansour
Publication year - 2019
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/cge.13498
Subject(s) - rheumatoid arthritis , pathogenesis , etiology , medicine , immunology , autoimmune disease , disease , genetic predisposition , inflammation , arthritis , bioinformatics , biology , pathology , antibody
Rheumatoid arthritis (RA) is a systemic autoimmune disease that causes chronic inflammation of the joints. RA is a heterogeneous disorder caused by an abnormal autoimmune response triggered by the complex interactions of genetic and environmental factors that contribute to RA etiology. However, its underlying pathogenic mechanisms are yet to be fully understood. In this review, I provide an overview of the pathogenesis, diagnosis and therapeutic insight in the clinical management of RA in light of the recent updates to classification criteria and recent discoveries of genetic loci associated with susceptibility for RA.