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Systematic approach to understanding the pathogenesis of systemic sclerosis
Author(s) -
Zuo Xiaoxia,
Zhang Lihua,
Luo Hui,
Li Yisha,
Zhu Honglin
Publication year - 2017
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/cge.12946
Subject(s) - pathogenesis , disease , mechanism (biology) , identification (biology) , epigenesis , epigenetics , bioinformatics , genomics , computational biology , scleroderma (fungus) , medicine , metabolomics , biology , immunology , genetics , genome , pathology , gene , dna methylation , gene expression , philosophy , botany , epistemology , inoculation
Systemic sclerosis ( SSc ) is a complex heterogeneous autoimmune disease. Progressive organ fibrosis is a major contributor to SSc mortality. Despite extensive efforts, the underlying mechanism of SSc remains unclear. Efforts to understand the pathogenesis of SSc have included genomics, epigenetics, transcriptomic, proteomic and metabolomic studies in the last decade. This review focuses on recent studies in SSc research based on multi‐omics. The combination of these technologies can help us understand the pathogenesis of SSc . This review aims to provide important information for disease identification, therapeutic targets and potential biomarkers.