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Disclosing genetic risk for coronary heart disease: effects on perceived personal control and genetic counseling satisfaction
Author(s) -
Robinson C.L.,
Jouni H.,
Kruisselbrink T.M.,
Austin E.E.,
Christensen K.D.,
Green R.C.,
Kullo I.J.
Publication year - 2016
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/cge.12577
Subject(s) - medicine , genetic counseling , family history , genetic testing , coronary heart disease , randomized controlled trial , framingham risk score , disease , risk assessment , demography , clinical psychology , genetics , biology , computer security , sociology , computer science
We investigated whether disclosure of coronary heart disease ( CHD ) genetic risk influences perceived personal control ( PPC ) and genetic counseling satisfaction ( GCS ). Participants ( n = 207, age: 45–65 years) were randomized to receive estimated 10‐year risk of CHD based on a conventional risk score ( CRS ) with or without a genetic risk score ( GRS ). Risk estimates were disclosed by a genetic counselor who also reviewed how GRS altered risk in those randomized to CRS + GRS . Each participant subsequently met with a physician and then completed surveys to assess PPC and GCS . Participants who received CRS + GRS had higher PPC than those who received CRS alone although the absolute difference was small (25.2 ± 2.7 vs 24.1 ± 3.8, p = 0.04). A greater proportion of CRS + GRS participants had higher GCS scores (17.3 ± 5.3 vs 15.9 ± 6.3, p = 0.06). In the CRS + GRS group, PPC and GCS scores were not correlated with GRS . Within both groups, PPC and GCS scores were similar in patients with or without family history (p = NS ). In conclusion, patients who received their genetic risk of CHD had higher PPC and tended to have higher GCS . Our findings suggest that disclosure of genetic risk of CHD together with conventional risk estimates is appreciated by patients. Whether this results in improved outcomes needs additional investigation.