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Genetics of sudden cardiac death in the young
Author(s) -
Saenen J.B.,
Van Craenenbroeck E.M.,
Proost D.,
Marchau F.,
Van Laer L.,
Vrints C.J.,
Loeys B.L.
Publication year - 2015
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/cge.12519
Subject(s) - sudden cardiac death , sudden death , pathogenesis , inheritance (genetic algorithm) , phenotype , genetics , medicine , genetic predisposition , feeling , biology , gene , psychology , social psychology
Sudden cardiac death ( SCD ) has an enormous impact on those who are left behind, evoking strong feelings of anxiety and incomprehension because such a dramatic event was not anticipated. Moreover, over the last decade a prominent genetic contribution to the pathogenesis of SCD has been unveiled. As many inherited cardiac diseases show an autosomal dominant pattern of inheritance, the risk of carrying the same inherited predisposition is a real concern for the relatives. In this article, we discuss the major causes of primary electrical disorders, cardiomyopathies and thoracic aortic dissection and address issues in genotype–phenotype correlation, personalized management and cardiogenetic counselling.