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Genetic epidemiology of tooth agenesis in Japan: a population‐ and family‐based study
Author(s) -
Machida J.,
Nishiyama T.,
Kishino H.,
Yamaguchi S.,
Kimura M.,
Shibata A.,
Tatematsu T.,
Kamamoto M.,
Yamamoto K.,
Makino S.,
Miyachi H.,
Shimozato K.,
Tokita Y.
Publication year - 2015
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/cge.12456
Subject(s) - hypodontia , oligodontia , sibling , renal agenesis , agenesis , confidence interval , etiology , medicine , epidemiology , permanent teeth , population , dentistry , surgery , psychology , developmental psychology , environmental health , kidney
Tooth agenesis is one of the most common congenital anomalies in humans. However, the etiology of tooth agenesis remains largely unclear, as well as evidence base useful for genetic counseling. Therefore, we estimated the prevalence and sibling recurrence risk, and investigated agenetic patterns systematically. Tooth agenesis was classified into two subtypes: hypodontia (one to five missing teeth) and oligodontia (six or more missing teeth). The prevalence of these two subtypes were 6.8% [95% confidence interval ( CI ): 6.1–7.7%] and 0.1% (95% CI : 0.04–0.3%), respectively, and sibling recurrence risk of these were 24.5% (95% CI : 13.8–38.3%) and 43.8% (95% CI : 26.4–62.3%), respectively. This result suggests that the severe phenotype, oligodontia, might be mostly transmitted in a dominant fashion. Using a simple statistical modeling approach, our data were found to be consistent with a bilateral symmetry model, meaning that there was equal probability of missing teeth from the right and left sides.