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Age‐related macular degeneration—clinical review and genetics update
Author(s) -
Ratnapriya R,
Chew E Y
Publication year - 2013
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/cge.12206
Subject(s) - macular degeneration , etiology , disease , medicine , genetic testing , precision medicine , personalized medicine , intervention (counseling) , human genetics , genomics , medical genetics , bioinformatics , genetics , pathology , biology , gene , genome , ophthalmology , psychiatry
Age‐related macular degeneration ( AMD ) is the leading cause of central vision impairment in persons over the age of 50 years in developed countries. Both genetic and non‐genetic (environmental) factors play major roles in AMD etiology, and multiple gene variants and lifestyle factors such as smoking have been associated with the disease. While dissecting the basic etiology of the disease remains a major challenge, current genetic knowledge has provided opportunities for improved risk assessment, molecular diagnosis and clinical testing of genetic variants in AMD treatment and management. This review addresses the potential of translating the wealth of genetic findings for improved risk prediction and therapeutic intervention in AMD patients. Finally, we discuss the recent advancement in genetics and genomics and the future prospective of personalized medicine in AMD patients.