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The M694V mutation in Armenian‐Americans: a 10‐year retrospective study of MEFV mutation testing for familial Mediterranean fever at UCLA
Author(s) -
Ong FS,
Vakil H,
Xue Y,
Kuo JZ,
Shah KH,
Lee RB,
Bernstein KE,
Rimoin DL,
Getzug T,
Das K,
Deignan JL,
Rotter JI,
Grody WW
Publication year - 2013
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/cge.12029
Subject(s) - mefv , familial mediterranean fever , medicine , mutation , gene mutation , rash , amyloidosis , population , disease , immunology , genetics , gene , biology , environmental health
Familial Mediterranean fever ( FMF ), inherited in an autosomal recessive manner, is a systemic auto‐inflammatory disorder characterized by recurrent attacks of fever with peritonitis, pleuritis, synovitis and erysipeloid rash. The marenostrin‐encoding fever ( MEFV ) gene, located on chromosome 16p13.3, is the only gene in which mutations are currently known to cause FMF . To correlate specific genotypes with adverse phenotypes of affected populations residing in the Western United States, a retrospective case series review was conducted of all MEFV gene mutation testing completed at UCLA Clinical Molecular Diagnostic Laboratory between February 2002 and February 2012, followed by clinical chart review of all subjects who either have a single or double mutation. All 12 common mutations in the MEFV gene were analyzed and the M694V variant was found to be associated with an adverse FMF clinical outcome in the Armenian‐American population, manifested by earlier onset of disease, increased severity of disease, and renal amyloidosis.