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Aplasia of the Optic Nerve in Microphthalmic Offspring of Prenatally X‐irradiated Rats
Author(s) -
Takeuchi Yoshiko K.,
Kitoh Junzoh,
Sakai Hisashi,
Takeuchi Ikuo K.
Publication year - 1988
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.1988.28.3.179
Subject(s) - aplasia , optic nerve , optic nerve hypoplasia , hypoplasia , major duodenal papilla , medicine , anatomy , offspring , ganglion , pathology , biology , pregnancy , genetics
A considerable number of postnatally‐viable microphthalmic offspring with optic nerves completely absent were obtained by X‐irradiation at a dose of 100 R in pregnant rats on gestational day 10.5. Thirteen of 15 mi‐crophthalmic eyes examined displayed histological features characteristic of aplasia of the optic nerve: complete absence of optic papilla, nerve fiber layer and retinal blood vessels, and great reduction in the number of ganglion cells. The remaining 2 eyes showed the histological features of hypoplasia of the optic nerve. The present experimental system may afford suitable materials for postnatal patho‐genetic studies and also for various physiological and behavioral studies of aplasia of the optic nerve.