Premium
Issue Information
Publication year - 2020
Publication title -
congenital anomalies
Language(s) - English
Resource type - Reports
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12340
Subject(s) - embryonic stem cell , microbiology and biotechnology , mutant , biology , bone morphogenetic protein 4 , anatomy , genetics , gene
Murine genital tubercle (GT) initiates its outgrowth from embryonic posterior body trunk. Hoxa3‐Cre ‐mediated Bmp4 cKO mice showed the defective GT outgrowth with reduced p63 expression. However, Shh expression was not affected in the mutant mice. This report suggests Bmp4 regulates the initiation of GT outgrowth by controlling p63 expression, which is independent of Shh signaling. Further details can be seen in the original article by Kajioka et al. in this issue.