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Developmental toxicity of flucytosine following administration to pregnant rats at a specific time point of organogenesis
Author(s) -
Fujii Sakiko,
Yabe Kaoru,
KariwanoKimura Yuki,
Furukawa Masatoshi,
Itoh Kouta,
Matsuura Masao,
Horimoto Masao
Publication year - 2019
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12282
Subject(s) - organogenesis , toxicity , developmental toxicity , medicine , pregnancy , biology , physiology , pharmacology , fetus , genetics , gene
To investigate the abnormalities that are specific to administration of flucytosine at one time point during embryonic organogenesis, flucytosine was administered orally to pregnant Sprague Dawley (SD) rats in a single dose on day 11 of pregnancy at 25 or 35 mg/kg. Fetuses on day 20 of pregnancy were externally, viscerally, and skeletally examined. Maternal body weight gain and food consumption were suppressed the day after administration of a 35 mg/kg. Fetal examinations revealed various alterations in both dose groups: externally preaxial polydactyly in the hind limb; skeletally fused lumbar centrum, absent sacral centrum, supernumerary sacral vertebra, and absent ribs. Our findings indicated that specific types of external and skeletal anomalies were induced following flucytosine administration on day 11 of pregnancy.