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Regional difference in sulcal infolding progression correlated with cerebral cortical expansion in cynomolgus monkey fetuses
Author(s) -
Sawada Kazuhiko,
Fukunishi Katsuhiro,
Kashima Masatoshi,
Imai Noritaka,
Saito Shigeyoshi,
Aoki Ichio,
Fukui Yoshihiro
Publication year - 2017
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12209
Subject(s) - gyrification , anatomy , fetus , cerebral cortex , biology , medicine , neuroscience , pregnancy , genetics
The present study aimed to specify the cerebral sulci developed by cortical expansion in cynomolgus monkey fetuses. The degree of sulcal infolding was evaluated by the gyrification index (GI), which was quantified using ex vivo magnetic resonance imaging. The correlation of cortical volume with the sulcal GI was most frequent during embryonic days (EDs) 100 to 120. Interestingly, the high correlation was marked during EDs 140 to 150 in restricted primary sulci in prefrontal, parietotemporal and medial temporal regions. The present results suggest that cortical expansion is involved in gyral demarcation by sulcal infolding, followed by the sulcal infolding progression in phylogenetically‐newer cortices.