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Issue Information
Publication year - 2017
Publication title -
congenital anomalies
Language(s) - English
Resource type - Reports
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12184
Subject(s) - induced pluripotent stem cell , citation , chromosome , computer science , information retrieval , genetics , computational biology , medicine , world wide web , biology , embryonic stem cell , gene
Induced pluripotent stem cells derived from a Prader‐Willi syndrome (PWS) patient harboring a deletion on chromosome 15q11.2. The fully methylated chromosome 15q11.2 in PWS‐fibroblasts was successfully reversed to a partially unmethylated status in some PWS‐iPSC lines. Cell replacement‐based therapeutic strategy could be a promising strategy by the reversal of hypermethylation. Further details can be seen in the article by Okuno et al. in this issue.