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Prevalence of congenital limb defects: Data from birth defects registries in three provinces in Southern Thailand
Author(s) -
Jaruratanasirikul Somchit,
Tangtrakulwanich Boonsin,
Rachatawiriyakul Pornruedee,
Sriplung Hutcha,
Limpitikul Wannee,
Dissaneevate Pathikan,
Khunnarakpong Nattasit,
Tantichantakarun Pongsak
Publication year - 2016
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12154
Subject(s) - medicine , syndactyly , polydactyly , pediatrics , pregnancy , obstetrics , population , gestational age , surgery , genetics , environmental health , anatomy , biology
This is the first population‐based study in Thailand on the prevalence of congenital limb defects (CLD). Data were obtained from recently established birth defects registries in three southern Thailand provinces during 2009–2013. Entries in the birth defects registries included live births, stillbirths after 24 weeks gestational age, and terminations of pregnancy following a prenatal diagnosis of fetal anomaly. The total of 186 393 births recorded included 424 CLD cases, giving an average prevalence of 2.27 per 1000 births (95% CI, 2.05–2.49). The most common CLD was talipes equinovarus (44.1%), followed by polydactyly (13.9%) and syndactyly (9.4%). The prevalence significantly increased with maternal age from 1.81 in mothers aged <30 years to 2.75 in mothers 30 to < 35 years, and to 2.94 in mothers ≥35 years ( P = 0.004). Overall 9.4% of the CLDs were syndromic CLD, again with significantly greater percentages in pregnant women aged ≥35 years than the non‐syndromic CLD (32.5% vs 17.5% respectively, P = 0.03). In conclusion, the overall prevalence of CLD in the 3 southern Thailand provinces examined was 2.27 per 1000 births, and syndromic CLD was significantly higher in pregnant women aged ≥35 years than younger pregnant women.