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Correlation of external ear auricle formation with staging of human embryos
Author(s) -
OzekiSato Maimi,
Yamada Shigehito,
Uwabe Chigako,
Ishizu Koichi,
Takakuwa Tetsuya
Publication year - 2016
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12140
Subject(s) - auricle , mesenchyme , embryo , anatomy , cartilage , biology , microbiology and biotechnology
The formation of auricles in human embryos was evaluated between Carnegie stage ( CS )19 and CS 23, and the findings were correlated across the stages. The auricle was categorized into 11 steps according to Streeter's criteria with modifications. Mesenchyme cell condensation was observed at Step 7, and two layers of cartilage consisting of the auricle were recognized at Step11. The representative steps at each CS shifted from Step 3 to Step11 during CS 16 and CS 23, although several steps overlapped between adjacent CSs . These results indicate that observations of the auricle between CS 19 and CS 23 may be utilized for determining embryo staging as convincing supportive evidence of external features reflecting the internal histological structure, although other findings should also be taken into account.