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Maternal factors in the origin of infantile hypertrophic pyloric stenosis: A population‐based case‐control study
Author(s) -
Vermes Gabor,
László Daniel,
Czeizel† Andrew E.,
Ács Nándor
Publication year - 2016
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12134
Subject(s) - hypertrophic pyloric stenosis , medicine , etiology , population , pediatrics , pyloric stenosis , nalidixic acid , pregnancy , case control study , obstetrics , antibiotics , environmental health , genetics , antibiotic resistance , microbiology and biotechnology , biology
In most patients affected by isolated infantile hypertrophic pyloric stenosis ( IHPS ) the etiology is largely unknown. Thus, the aim of this study was to estimate possible maternal risk factors in the origin of IHPS . The study samples included 241 cases with IHPS , 357 matched controls and 38 151 population controls without any defect in the population‐based large dataset of the H ungarian C ase‐ C ontrol S urveillance of C ongenital A bnormalities, 1980–1996. Exposures that had been medically recorded in prenatal maternity logbooks during the critical period of IHPS were evaluated separately. The findings of this case‐control study suggested that – beyond the well‐known robust male excess (85.5%) – maternal hyperthyroidism ( OR with 95% CI : 4.17, 1.53–11.38) and oral nalidixic acid treatment ( OR with 95% CI : 6.53, 3.03–14.06) associated with a higher risk for IHPS in their children. In conclusion, our findings suggest that cases with IHPS had mothers with a higher proportion of hyperthyroidism and nalidixic acid treatment during pregnancy.