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Growth patterns of C hinese patients with P rader‐ W illi syndrome
Author(s) -
Yang Hongbo,
Zhang Mengqi,
Song Hongmei,
Zhu Huijuan,
Pan Hui
Publication year - 2015
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12111
Subject(s) - medicine , growth curve (statistics) , pediatrics , body mass index , population , mainland china , obesity , chinese population , biology , china , genetics , mathematics , environmental health , political science , law , genotype , econometrics , gene
The aim of the present study was to investigate the spontaneous development of growth and weight gain of patients with P rader‐ W illi syndrome ( PWS ) in M ainland C hina. We retrospectively analyzed 120 cases of PWS diagnosed from 1994 to 2014 in M ainland C hina. Scatter diagram of the growth data was compared to standardized growth curve. The length at birth was similar to the normal population and the mean birthweight is under the 50th centile of normal population. Heights in 43% (27/62) of patients had dropped off below the 3 rd centile of their peers after 5 years of age. Weights in 65.9% (58/88) of patients had exceeded the 97 th centile of their peers after 3 years of age. Early obesity is obvious in 92.9% (66/71) of patients with body mass index ( BMI) up the 97 th centile of their peers from 2–3 years of age. Final mean height is 149.3 ± 11.2 cm for females ( n = 7) and 146.2 ± 9.8 cm for males ( n = 6), showing 11.3 cm and 26.6 cm below the average height for normal Chinese girls and boys. The growth pattern of PWS in M ainland C hina is comparable to those in C aucasians. Early intervention with recombinant human growth hormone is warranted considering the early onset of growth retardation and obesity.