Premium
Fetal cytomegalovirus infection manifesting as transient pancytopenia
Author(s) -
Kiyokoba Ryo,
Hidaka Nobuhiro,
Sakata Yukiyo,
Hachisuga Kazuhisa,
Fukushima Kotaro,
Kato Kiyoko
Publication year - 2015
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12104
Subject(s) - pancytopenia , medicine , fetus , cytomegalovirus , umbilical cord , pulmonary hypoplasia , hypoplasia , pregnancy , surgery , immunology , herpesviridae , bone marrow , human immunodeficiency virus (hiv) , viral disease , genetics , biology
Abstract We encountered a patient with a fetal cytomegalovirus infection manifesting as pancytopenia and thoracic hypoplasia. The fetal anemia was treated by transfusion via the umbilical cord, and did not progress after 22 weeks' gestation. The neutropenia resolved spontaneously, and only thrombocytopenia was persistent at birth. The severe thoracic hypoplasia led to pulmonary hypertension and required intensive postnatal respiratory management. Our experience suggests that pancytopenia is a possible manifestation in fetuses infected with cytomegalovirus. This may be transient, resolving spontaneously during fetal life; however, caution should be taken with blood counts, particularly platelet counts, after delivery. In addition, clinicians should carefully follow the thoracic volume in cytomegalovirus‐infected fetuses and consider the possibility of postnatal severe respiratory insufficiency.