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Prenatal findings of holoprosencephaly
Author(s) -
Hayashi Yuko,
Suzumori Nobuhiro,
Sugiura Tokio,
SugiuraOgasawara Mayumi
Publication year - 2015
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12103
Subject(s) - holoprosencephaly , trisomy , cyclopia , medicine , fetus , prenatal diagnosis , abnormality , gestation , aneuploidy , forebrain , chromosomal abnormality , pediatrics , pregnancy , obstetrics , karyotype , biology , chromosome , central nervous system , genetics , psychiatry , gene
Holoprosencephaly ( HPE ) is a rare brain abnormality characterized by an incomplete cleavage of the primitive prosencephalon of forebrain during early embryogenesis. To determine the clinical characteristics and outcome of fetuses with HPE , we retrospectively analyzed nine patients who were prenatally diagnosed as fetal HPE by ultrasounds. The mean diagnostic weeks were 20 weeks of gestation. Two cases died within one day after birth. The chromosomal examinations were performed in seven cases (trisomy 18: n = 2; trisomy 13: n = 2; 45, XX ,der(18)t(18;21)(p10;p10)mat: n = 1; normal karyotype: n = 2). In our HPE cases, most cases had serious facial anomalies and poor prognosis. Our data suggested that the early prenatal diagnosis of HPE allowed time for parental counseling and delivery planning.