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Polygenic expression of teratozoospermia and normal fertility in B 10. MOL ‐ TEN 1 mouse strain
Author(s) -
Hirawatari Keitaro,
Hanzawa Naoto,
Kuwahara Maki,
Aoyama Hiroaki,
Miura Ikuo,
Wakana Shigeharu,
Gotoh Hideo
Publication year - 2015
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12102
Subject(s) - sperm , biology , infertility , fertility , andrology , male infertility , male fertility , phenotype , strain (injury) , genotype , genetics , gene , population , medicine , anatomy , pregnancy , environmental health
Subfertility and infertility are two major reproductive health problems in human and domestic animals. The contribution of the genotype to these conditions is poorly understood. To examine the genetic basis of male subfertility, we analyzed its relationship to sperm morphology in B 10. MOL ‐ TEN 1 mice, which shows high‐frequencies (about 50%) of morphologically abnormal sperm. Drastic histological changes were also found in the testis of the B 10. MOL ‐ TEN 1. Segregation analysis showed that the abnormal sperm phenotype in B 10. MOL ‐ TEN 1 was inherited and was predictably controlled by at least three loci. We also found that male fertility of this strain was normal. These findings indicate a complicated relationship between sperm morphology and male subfertility.