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Congenital diseases and semaphorin signaling: Overview to date of the evidence linking them
Author(s) -
Masuda Tomoyuki,
Taniguchi Masahiko
Publication year - 2015
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12095
Subject(s) - semaphorin , plexin , biology , regulator , neuroscience , morphogenesis , angiogenesis , axon guidance , signal transduction , immunology , receptor , microbiology and biotechnology , genetics , gene , axon
Semaphorins and their receptors, neuropilins and plexins, were initially characterized as a modulator of axonal guidance during development, but are now recognized as a regulator of a wide range of developmental events including morphogenesis and angiogenesis, and activities of the immune system. Owing to the development of next‐generation sequencing technologies together with other useful DNA assays, it has also become clear that semaphorin signaling plays a crucial role in many congenital diseases such as retinal degeneration and congenital heart defects. This review summarizes the recent knowledge about the relationship between a variety of congenital diseases and semaphorin signaling.