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Sex ratio of congenital abnormalities in the function of maternal age: A population‐based study
Author(s) -
Csermely Gyula,
Urbán Robert,
Czeizel Andrew E,
Veszprémi Béla
Publication year - 2015
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12093
Subject(s) - anencephaly , medicine , craniosynostosis , population , age groups , pediatrics , sex ratio , fetus , pregnancy , demography , surgery , biology , genetics , environmental health , sociology
Maternal age effect is well‐known in the origin of numerical chromosomal aberrations and some isolated congenital abnormalities ( CA s). The sex ratio ( SR ), i.e. number of males divided by the number of males and females together, of most CA s deviates from the SR of newborn population (0.51). The objective of this analysis was to evaluate the possible association of maternal age with the SR of isolated CA s in a population‐based large dataset of the H ungarian Case‐Control Surveillance of Congenital Abnormalities, 1980–1996. First, SR of 24 CA entities/groups was estimated in 21 494 patients with isolated CA . In the next step SR of different maternal age groups was compared to the mean SR of the given CA ‐groups. The SR of four CA ‐groups showed some deviation in certain maternal age groups. Cases with anencephaly had female excess in young mothers (<25 years). Cases with skull's CA s particularly craniosynostosis had a male excess in cases born to women over 30 years. Two other CA groups (cleft lip ± palate and valvar pulmonic stenosis within the group of right‐sided obstructive defect of heart) had significant deviation in SR of certain maternal age groups from the mean SR , but these deviations were not harmonized with joining age groups and thus were considered as a chance effect due to multiple testing. In conclusion, our study did not suggest that in general SR of isolated CA s might be modified by certain maternal age groups with some exception such as anencephaly and craniosynostosis.