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Prevalence and risk factors for gastroschisis in a public hospital from west M éxico
Author(s) -
RobledoAceves Mireya,
BobadillaMorales Lucina,
MellínSánchez Estrella Lizbeth,
CoronaRivera Alfredo,
PérezMolina J. Jesús,
CárdenasRuiz Velasco Juan José,
CoronaRivera Jorge Román
Publication year - 2015
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12087
Subject(s) - gastroschisis , medicine , odds ratio , pregnancy , obstetrics , confidence interval , demography , pediatrics , fetus , genetics , sociology , biology
M exico is recognized as a country with a high prevalence of gastroschisis, although the cause of this remains unclear. We define the prevalence and potential risk factors for gastroschisis in a public hospital from west M éxico. A case‐control study was conducted among 270 newborns, including 90 patients with nonsyndromic gastroschisis (cases) and 180 infants without birth defects (controls), born all during the period 2009 to 2013 at the H ospital C ivil de G uadalajara “ D r. J uan I . M enchaca” ( G uadalajara, M exico), from a total of 51 145 live births. Potential maternal risk factors for gastroschisis were compared using multivariate logistic regression analysis to evaluate the deviance explained by different variables of interest. The overall prevalence of gastroschisis in live births was 17.6 per 10 000 births (95% confidence interval [ CI ] 14.0–21.2), whereas in offspring of women ≤19 years old was 29.9 per 10 000 births (95% CI 21.9–38.0). Mothers ≤19 years (adjusted odds ratio [ aOR ] 2.8: 95% CI 1.5–5.1), anemia during pregnancy ( aOR 10.7; 95% CI 2.0–56.9), first‐trimester exposure to hormonal contraceptives ( aOR 3.7; 95% CI 1.0–13.0), and first‐trimester alcohol consumption ( aOR 3.4; 95% CI 1.6–7.3), were associated with gastroschisis. Contrarily, adjusted OR for pre‐pregnancy body mass index ≥25 kg/m 2 has protective odds ( aOR 0.2; 95% CI 0.1–0.5). Our results suggest an increased risk for gastroschisis among mothers under the age of 20, with anemia during pregnancy, and those who used hormonal contraceptives or consumed alcohol during early pregnancy, whereas, pre‐pregnancy overweight has a protective OR , and they are discussed as clues in its pathogenesis.