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Dose‐related cerebellar abnormality in rats with prenatal exposure to X ‐irradiation by magnetic resonance imaging volumetric analysis
Author(s) -
Sawada Kazuhiko,
Saito Shigeyoshi,
HoriuchiHirose Miwa,
Mori Yuki,
Yoshioka Yoshichika,
Murase Kenya
Publication year - 2013
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/cga.12016
Subject(s) - magnetic resonance imaging , cerebellum , nuclear medicine , white matter , medicine , irradiation , hypoplasia , cerebellar hypoplasia (non human) , anatomy , nuclear magnetic resonance , radiology , physics , nuclear physics
Cerebellar abnormalities in 4‐week‐old rats with a single whole body X ‐irradiation at a dose of 0.5, 1.0, or 1.5 G y on embryonic day ( ED ) 15 were examined by magnetic resonance imaging ( MRI) volumetry. A 3 D T 2 W‐MRI anatomical sequence with high‐spatial resolution at 11.7‐tesla was acquired from the fixed rat heads. By MRI volumetry, whole cerebellar volumes decreased dose‐dependently. Multiple linear regression analysis revealed that the cortical volume (standardized β = 0.901; P < 0.001) was a major explanatory variable for the whole cerebellar volume, whereas both volumes of the white matter and deep cerebellar nuclei also decreased depending on the X ‐irradiation dose. The present MRI volumetric analysis revealed a dose‐related cerebellar cortical hypoplasia by prenatal exposure to X ‐irradiation on E 15.