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Use of trypan blue to assess lymphatic function following trabeculectomy
Author(s) -
Khoo Ying J.,
Abdullah Aulia A. H.,
Yu DaoYi,
Morgan William H.
Publication year - 2019
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.13534
Subject(s) - trabeculectomy , medicine , trypan blue , intraocular pressure , lymphatic system , glaucoma , bleb (medicine) , ophthalmology , surgery , pathology , cell , biology , genetics
Importance To illustrate the importance of lymphatic drainage in assessing trabeculectomy bleb function using intracameral trypan blue. Background To study the lymphatic drainage of trabeculectomy blebs using trypan blue, correlate with bleb function and classify them accordingly. Design Prospective cross‐sectional study in a tertiary care centre. Participants Thirteen glaucoma patients post‐trabeculectomy were studied. Methods Trypan blue was injected into the anterior chamber. Main Outcome Measures The duration taken for dye to stain a drainage bleb or lymphatics is recorded. The extent of the lymphatic structures were measured in clock hours. Intraocular pressure (IOP) prior to surgery was recorded. Results Eight post‐trabeculectomy subjects with dye stained lymphatic vessels had lower IOP (12.6 mmHg, P = .013) compared to the five with no lymphatic vessel staining (mean IOP 23.6 mmHg). Lymphatic extent was inversely related to IOP ( P = .021). Conclusions and Relevance Eyes with lymphatic connections to drainage blebs had lower IOP and reduced requirement for topical medications. The extent of lymphatic connection to drainage blebs is related to lower IOP.