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Progression of retinitis pigmentosa on multimodal imaging: The PREP‐1 study
Author(s) -
Iftikhar Mustafa,
Usmani Bushra,
Sanyal Abanti,
Kherani Saleema,
Sodhi Simrat,
Bagheri Saghar,
Schönbach Etienne M.,
Junaid Nadia,
Scholl Hendrik P. N.,
Shah Syed M. A.
Publication year - 2019
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.13458
Subject(s) - medicine , microperimetry , retinitis pigmentosa , ophthalmology , visual acuity , optical coherence tomography , nuclear medicine , fundus (uterus) , retinal
Importance It is important to establish reliable outcome measures to detect progression in retinitis pigmentosa (RP). Background To evaluate progression of RP using multimodal imaging, including spectral‐domain optical coherence tomography (SD‐OCT), fundus autofluorescence (FAF) and microperimetry (MP). Design Retrospective longitudinal study at a tertiary teaching hospital. Participants 205 eyes of 106 patients with RP with 1 to 5 y of follow‐up. Methods Demographics and visual acuity (VA) were recorded, and each modality was graded at baseline and every annual follow‐up. SD‐OCT was graded for the width of ellipsoid zone (EZ), FAF was graded for the diameter and area of the hyperautofluorescent ring (if present), and MP was graded for mean, central and paracentral sensitivity. Spearman's correlation was used to measure correlations at baseline. Mixed effects models were used to estimate the annual change of each parameter, adjusted for disease duration. Main Outcome Measures Rate of progression. Results The median VA at baseline was 75 letters and was positively correlated with mean and central sensitivity ( r : 0.372 and 0.394; P = 0.01 for both). All parameters (except paracentral sensitivity) were strongly correlated with each other ( r : 0.673‐0.991; P < 0.001 for all). The annual rates of change for each parameter were as follows: VA, −2.3 letters ( P < 0.001); EZ, −151 μm ( P < 0.001); ring diameter, −132 μm ( P < 0.001); ring area, −0.4 mm 2 ( P < 0.001); mean sensitivity, −0.3 dB ( P < 0.001); central sensitivity, −0.7 dB ( P < 0.001); paracentral sensitivity, −0.4 dB ( P < 0.001). Conclusions and Relevance Structural and functional measures are well correlated in RP and can reliably measure disease progression within the course of a year.