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Steady‐state pattern electroretinogram and short‐duration transient visual evoked potentials in glaucomatous and healthy eyes
Author(s) -
Amarasekera Dilru C,
Resende Arthur F,
Waisbourd Michael,
Puri Sanjeev,
Moster Marlene R,
Hark Lisa A,
Katz L Jay,
Fudemberg Scott J,
Mantravadi Anand V
Publication year - 2017
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.13006
Subject(s) - medicine , stimulus (psychology) , glaucoma , ophthalmology , electrophysiology , evoked potential , audiology , electroretinography , contrast (vision) , visual evoked potentials , retinal , optics , psychology , physics , psychotherapist
Abstract Importance This study evaluates two rapid electrophysiological glaucoma diagnostic tests that may add a functional perspective to glaucoma diagnosis. Background This study aimed to determine the ability of two office‐based electrophysiological diagnostic tests, steady‐state pattern electroretinogram and short‐duration transient visual evoked potentials, to discern between glaucomatous and healthy eyes. Design This is a cross‐sectional study in a hospital setting. Participants Forty‐one patients with glaucoma and 41 healthy volunteers participated in the study. Methods Steady‐state pattern electroretinogram and short‐duration transient visual evoked potential testing was conducted in glaucomatous and healthy eyes. A 64‐bar‐size stimulus with both a low‐contrast and high‐contrast setting was used to compare steady‐state pattern electroretinogram parameters in both groups. A low‐contrast and high‐contrast checkerboard stimulus was used to measure short‐duration transient visual evoked potential parameters in both groups. Main Outcome Measures Steady‐state pattern electroretinogram parameters compared were MagnitudeD, MagnitudeD/Magnitude ratio, and the signal‐to‐noise ratio. Short‐duration transient visual evoked potential parameters compared were amplitude and latency. Results MagnitudeD was significantly lower in glaucoma patients when using a low‐contrast ( P = 0.001) and high‐contrast ( P < 0.001) 64‐bar‐size steady‐state pattern electroretinogram stimulus. MagnitudeD/Magnitude ratio and SNR were significantly lower in the glaucoma group when using a high‐contrast 64‐bar‐size stimulus ( P < 0.001 and P = 0.010, respectively). Short‐duration transient visual evoked potential amplitude and latency were not significantly different between the two groups. Conclusions and relevance Steady‐state pattern electroretinogram was effectively able to discern between glaucomatous and healthy eyes. Steady‐state pattern electroretinogram may thus have a role as a clinically useful electrophysiological diagnostic tool.