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Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents
Author(s) -
Tsatsos Michael,
MacGregor Cheryl,
Athanasiadis Ioannis,
Moschos Marilita M,
Hossain Parwez,
Anderson David
Publication year - 2016
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12785
Subject(s) - medicine , keratitis , herpes simplex virus , dermatology , pathogenesis , aciclovir , disease , herpesviridae , immunology , virology , viral disease , virus , pathology
Ophthalmic herpes simplex viral keratitis is responsible for a range of ocular manifestations from superficial epithelial disease to stromal keratitis and endotheliitis. The Herpetic Eye Disease Study has guided the management of herpetic eye disease for almost twenty years, but newer medications such as valacyclovir are now available and are considered to have better bioavailability than acyclovir. In this review, we examine the existing evidence on the pathogenesis of different ophthalmic herpes simplex viral keratitis disease modalities and the role of oral and topically administered antiviral drugs in the treatment of herpes simplex viral keratitis.