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Peripapillary retinal nerve fibre layer thickness and its association with refractive error in Chinese children: the Anyang Childhood Eye Study
Author(s) -
Kang MengTian,
Li ShiMing,
Li He,
Li Lei,
Li SiYuan,
Zhu BiDan,
Guo YiQin,
Meng Bo,
Sun YunYun,
Ran Anran,
Wang YiPeng,
Liu LuoRu,
Zhan SiYan,
Thomas Ravi,
Wang Ningli
Publication year - 2016
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12764
Subject(s) - emmetropia , medicine , retinal , ophthalmology , refractive error , optic nerve , nerve fiber layer , optical coherence tomography , visual acuity
Background To report the thickness of the peripapillary retinal nerve fibre layer (pRNFL) in Chinese children and examine its association with refractive error, axial length (AL) and optic disc parameters. Design Population‐based cross‐sectional study. Participants A total of 2893 seven‐year‐old children from 11 randomly selected primary schools in Anyang, central China. Methods Participants underwent ophthalmic examinations including optical biometry, cycloplegic autorefraction and spectral‐domain ocular coherence tomography. Main Outcome Measures Retinal nerve fibre layer thickness in 16 radial sections, cycloplegic spherical equivalent, AL. Results The mean (SD) average RNFL thickness was 102.01(8.02) µm. The average RNFL thickness decreased with smaller disc area ( r = 0.18, R 2 = 0.03, P < 0.0001), bigger cup area ( r = −0.11, R 2 = 0.01, P < 0.0001), smaller rim area ( r = 0.28, R 2 = 0.08, P < 0.0001), smaller nerve head volume ( r = 0.27, R 2 = 0.07, P < 0.0001), longer AL ( r = −0.15, R 2 = 0.02, P < 0.0001) and a negative spherical equivalent ( r = 0.11, R 2 = 0.01, P < 0.0001). Hyperopic children had a thicker RNFL than emmetropic children [102.45(8.13) µm vs . 100.81 (7.18) µm, P < 0.001]. Myopic children had thinner RNFL than emmetropic children [99.17 (7.69) µm vs . 100.81 (7.18) µm, P < 0.05]. Conclusion Retinal nerve fibre layer thickness decreased with increasing AL, higher myopia, bigger cup area, smaller disc and rim area, and a smaller nerve head volume, but the coefficient of determination for all these associations was small. The RNFL in myopes was significantly thinner than emmetropes or hyperopes, but with small absolute differences. The study provides RNFL values for healthy 7‐year‐old Chinese children. Follow up of this cohort to observe the change of RNFL thickness with myopia and possible change in detected associations with age is planned.