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Six‐year incidence of visually significant age‐related cataract: the Chennai eye disease incidence study
Author(s) -
Panday Manish,
George Ronnie,
Asokan Rashima,
Ve Ramesh Satyamangalam,
Velumuri Lokapavani,
Choudhari Nikhil S,
Boddupalli Sachi Devi,
Sunil Govindan T,
Vijaya Lingam
Publication year - 2016
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12636
Subject(s) - medicine , aphakia , incidence (geometry) , cataract surgery , ophthalmology , visual acuity , cohort , population , cohort study , odds ratio , pseudophakia , optometry , physics , environmental health , optics
Background The aim of this study is to report the 6‐year incidence of age‐related cataract in a population‐based study. Design The design used is a population‐based cohort study. Participants A cohort of 2484 phakic subjects, aged 40 years and above at baseline, from a south Indian population was included in the study. Methods Bilateral phakics with visual acuity of 6/12 or better and cataract less than N2, C2 and P2 on the Lens Opacities Classification System II at baseline were included. Subjects with glaucoma and corneal or retinal diseases were excluded. Incident visually significant cataract was defined as visual acuity of less than 6/18 with a corresponding one grade or greater change in Lens Opacities Classification System II or history of having undergone cataract surgery with evidence of pseudophakia or aphakia at the 6‐year follow‐up. Main Outcome Measures Six‐year incidence of visually significant cataract and associated risk factors data were collected. Results Incident visually significant cataract at 6 years was seen in 158 subjects (6.36%, 95% CI: 5.40–7.32, phakics:pseudophakics/aphakics 70:88). Incidence was higher in the rural cohort as compared with the urban cohort ( P < 0.001). Incidence increased with age and was highest in the ≥70 years age group (odds ratio (OR):31.23, 95% CI: 15.20–64.16, P < 0.001). Other associated risk factors included illiteracy (OR 1.75, 95% CI: 1.17–2.61, P = 0.007) and smoking (OR 1.77, 95% CI: 1.08–2.88, P = 0.02). Conclusions A significant proportion of the population developed visually significant age‐related cataract at 6 years. Incident visually significant cataract was significantly greater for the rural cohort between 50 and 69 years old.