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Cancer‐like metabolism of the mammalian retina
Author(s) -
Ng Soo Khai,
Wood John PM,
Chidlow Glyn,
Han Guoge,
Kittipassorn Thaksaon,
Peet Daniel J,
Casson Robert J
Publication year - 2014
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12462
Subject(s) - retina , cancer , retinal , medicine , glycolysis , cancer cell , anaerobic glycolysis , neuroscience , bioinformatics , metabolism , biology , ophthalmology
The retina, like many cancers, produces energy from glycolysis even in the presence of oxygen. This phenomenon is known as aerobic glycolysis and eponymously as the W arburg effect. In recent years, the W arburg effect has become an explosive area of study within the cancer research community. The expanding knowledge about the molecular mechanisms underpinning the W arburg effect in cancer promises to provide a greater understanding of mammalian retinal metabolism and has motivated cancer researchers to target the W arburg effect as a novel treatment strategy for cancer. However, if the molecular mechanisms underlying the W arburg effect are shared by the retina and cancer, treatments targeting the W arburg effect may have serious adverse effects on retinal metabolism. Herein, we provide an updated understanding of the W arburg effect in mammalian retina.