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Evaluation of the chorioretinal thickness changes in A lzheimer's disease using spectral‐domain optical coherence tomography
Author(s) -
Bayhan Hasan Ali,
Aslan Bayhan Seray,
Celikbilek Asuman,
Tanık Nermin,
Gürdal Canan
Publication year - 2015
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12386
Subject(s) - medicine , optical coherence tomography , ophthalmology , retinal , prospective cohort study , pathology
Abstract Background To assess the chorioretinal thickness changes using spectral‐domain optical coherence tomography ( SD‐OCT ) and to evaluate the association between these structural changes and cognitive impairment in A lzheimer's disease ( AD ). Design Prospective, cross‐sectional study Participants Thirty‐one eyes of 31 consecutive patients with AD and 30 eyes of 30 cognitively healthy age‐matched control subjects were recruited Methods SD‐OCT ( RTV ue‐100) was used to measure the macular ganglion cell complex thickness ( mGCC ), outer retinal thickness ( ORL ), and the choroidal thickness ( CT ). Cognitive function was evaluated by M ini‐ M ental S tate examination ( MMSE ) on the same day of the optical examination. Main Outcome Measures Chorioretinal thickness. Results The mGCC average, mGCC superior and mGCC inferior thicknesses of the AD group were significantly thinner than those of the controls (all, P < 0.05). No significant difference was found in the ORL thickness measurements between the two groups. Compared with control subjects, the CT measurements at all regions were significantly thinner in patients with AD than controls except CT measurement at 3.0 mm temporal to the fovea ( P = 0.067). Significant correlations between the mGCC thickness measurements of the AD group and MMSE scores were observed. There was no significant correlation between the MMSE scores and the CT measurements ( P > 0.05). Conclusions Patients with AD had chorioretinal structural alterations. Retinal structural alterations were seen only in the inner layers. The reduction in mGCC thickness parameters were related to the severity of cognitive impairment in AD .