Genetic polymorphism related to exfoliative glaucoma is also associated with primary open‐angle glaucoma risk

Background To investigate the possible association of the rs2165241 polymorphism ( C  >  T ) in LOXL1 gene with the risk of primary open‐angle glaucoma in a M editerranean population. Methods The analysis of genetic polymorphisms was performed by standard T aq M an allelic discrimination technique, using a 7900 HT S equence D etection S ystem ( A pplied B iosystems). Results In a recessive genetic model, the T allele of the rs2165241 polymorphism was significantly associated with the risk of primary open‐angle glaucoma ( TT vs. CC : odds ratios = 2.19, 95% confidence interval = [1.33–3.62]). After multivariate logistic regression model adjusted by age and weight, the magnitude of the association decreased but remained statistically significant ( TT vs. CC : odds ratios = 2.07, 95% confidence interval = [1.20–3.57]). Conclusion This polymorphism seems to be associated with high risk for primary open‐angle glaucoma in a M editerranean population.