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Genetic polymorphism related to exfoliative glaucoma is also associated with primary open‐angle glaucoma risk
Author(s) -
ZaMoreno Vicente,
ZaMoreno Laura,
OrtegaAzorin Carolina,
AsensioMarquez Eva M,
GarciaMedina Jose Javier,
Sanz Pedro,
PinazoDuran Maria D,
Ordovás Jose M,
Corella Dolores
Publication year - 2014
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12367
Subject(s) - medicine , open angle glaucoma , glaucoma , ophthalmology
Background To investigate the possible association of the rs2165241 polymorphism ( C > T ) in LOXL1 gene with the risk of primary open‐angle glaucoma in a M editerranean population. Methods The analysis of genetic polymorphisms was performed by standard T aq M an allelic discrimination technique, using a 7900 HT S equence D etection S ystem ( A pplied B iosystems). Results In a recessive genetic model, the T allele of the rs2165241 polymorphism was significantly associated with the risk of primary open‐angle glaucoma ( TT vs. CC : odds ratios = 2.19, 95% confidence interval = [1.33–3.62]). After multivariate logistic regression model adjusted by age and weight, the magnitude of the association decreased but remained statistically significant ( TT vs. CC : odds ratios = 2.07, 95% confidence interval = [1.20–3.57]). Conclusion This polymorphism seems to be associated with high risk for primary open‐angle glaucoma in a M editerranean population.