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Optic nerve head assessment: comparison of C irrus optic coherence tomography and H eidelberg R etinal T omograph 3
Author(s) -
Kratz Assaf,
Lim Ridia,
Goldberg Ivan
Publication year - 2014
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12344
Subject(s) - optical coherence tomography , cirrus , glaucoma , medicine , ophthalmology , optic nerve , receiver operating characteristic , optic disk , optic disc , tomography , nuclear medicine , remote sensing , radiology , geology
Background The purpose of this study was to analyse the relationship between optic nerve head ( ONH ) parameters measured by spectral domain optical coherence tomography and confocal scanning laser ophthalmoscope. Design Prospective, cross‐sectional study. Hospital setting. Participants One hundred seventy‐three subjects (85 glaucoma and 88 normal subjects). Methods One eye from each individual was selected randomly for ONH imaging by the spectral domain Cirrus OCT and Heidelberg Retinal Tomograph 3 ( HRT 3). Main Outcome Measures Four ONH parameters that are measured by both technologies (average cup‐to‐disc ratio [ CDR ], rim area, disc area and cup volume) were analysed and compared for differences, agreement of the categorical classification, diagnostic sensitivities and specificities and the area under the receiver operating characteristic curves ( AUC ). Results ONH parameters, as determined by the two technologies were significantly different but strongly correlated. Proportional bias was demonstrated for all measurements. The agreement of categorical classification was excellent for CDR (κ = 0.94) and good for rim area and cup volume (κ = 0.63 and 0.71, respectively). The highest sensitivities at fixed specificities were achieved by C irrus OCT . AUC s for CDR , rim area, disc area and cup volume were not significantly different between the two technologies. Conclusions The diagnostic capability of ONH measurements by both technologies is similar. Paired ONH measurements by C irrus OCT and HRT 3 are strongly correlated but significantly different and proportionally biased. The results preclude interchangeable use of the absolute values, but categorical classification of ONH parameters may be interchangeable in clinical practice.