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Meta‐analysis of methylprednisolone pulse therapy for G raves' ophthalmopathy
Author(s) -
Gao Guohong,
Dai Jinhui,
Qian Yifeng,
Ma Fei
Publication year - 2014
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12317
Subject(s) - medicine , methylprednisolone , confidence interval , adverse effect , meta analysis , relative risk , surgery , gastroenterology
A meta‐analysis was performed to evaluate the efficacy of methylprednisolone pulse therapy for G raves' ophthalmopathy. Eight studies involving 376 patients were included. A higher effective rate was found for patients treated with intravenous glucocorticoids ( IVGC ) over oral glucocorticoids (OGC) (risk ratio [ RR ] = 1.48; 95% confidence interval [ CI ] = 1.18−1.86). The combined IVGC and orbital radiotherapy ( OR ) was markedly more effective than OGC+OR ( RR = 1.40; 95% CI = 1.11−1.77). IVGC resulted in an obvious reduction of clinical activity score (CAS) compared with OGC , with a weighted mean difference ( WMD ) of 0.86 (95% CI = 0.53−1.18). The WMD for the reduction of the CAS between IVGC + OR and OGC + OR was 0.66 (95% CI = 0.30−1.02). IVGC is an effective treatment and cause fewer adverse events. Limiting the total cumulative dose of methylprednisolone, careful patient selection and monitoring the condition of patients during treatment are necessary.