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Correlation of magnetic resonance imaging optic nerve parameters to optical coherence tomography and the visual field in glaucoma
Author(s) -
Omodaka Kazuko,
Murata Takaki,
Sato Shiho,
Takahashi Mai,
Tatewaki Yasuko,
Nagasaka Tatsuo,
Doi Hiroshi,
Araie Makoto,
Takahashi Shoki,
Nakazawa Toru
Publication year - 2013
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12237
Subject(s) - magnetic resonance imaging , nerve fiber layer , glaucoma , optic nerve , optical coherence tomography , medicine , ophthalmology , retinal , diffusion mri , open angle glaucoma , nuclear magnetic resonance , physics , radiology
Abstract Background To determine the viability of using magnetic resonance imaging measurement of optic nerve morphology as an objective analysis of glaucomatous damage. Design Retrospective study conducted at T ohoku U niversity H ospital. Participants Thirty‐eight eyes of 19 patients with open‐angle glaucoma. Methods Patients were scanned with T 2‐weighted and 3‐ T diffusion tensor magnetic resonance imaging, and parameters of the optic nerve, including fractional anisotropy, apparent diffusion coefficient and cross‐sectional area, were determined. Conventional parameters of glaucomatous damage, including circumpapillary and macular retinal nerve fibre layer thickness, and mean deviation and average total deviation of the central 16 test points from the H umphrey F ield A nalyzer, were then compared with the magnetic resonance imaging‐derived parameters. S pearman's coefficient of correlation was calculated to determine the significance of the correlation.Main Outcome Measure Correlation coefficient between the magnetic resonance imaging parameters and the parameters of glaucomatous damage. Results Mean deviation was significantly correlated with all magnetic resonance imaging parameters (fractional anisotropy: r = 0.53, apparent diffusion coefficient: r = −0.44, cross‐sectional area: r = 0.70). Circumpapillary retinal nerve fibre layer thickness was significantly correlated with fractional anisotropy ( r = 0.60) and cross‐sectional area ( r = 0.47), but not apparent diffusion coefficient ( r = −0.29). Central macular function and macular retinal nerve fibre layer thickness were also significantly correlated with magnetic resonance imaging parameters. Conclusions Optic nerve magnetic resonance imaging parameters were significantly correlated to glaucomatous damage. Magnetic resonance imaging analysis of the optic nerve may, thus, have value as an objective instrument to assess glaucomatous degeneration, including the function of the macula.