Premium
Chromosome 9p21 primary open‐angle glaucoma susceptibility locus: a review
Author(s) -
Ng Soo Khai,
Casson Robert J,
Burdon Kathryn P,
Craig Jamie E
Publication year - 2013
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12234
Subject(s) - open angle glaucoma , genome wide association study , locus (genetics) , genetics , glaucoma , medicine , genetic association , chromosome , biology , genotype , ophthalmology , gene , single nucleotide polymorphism
Primary open‐angle glaucoma ( POAG ) is a genetically complex disease. Genome‐wide association study ( GWAS ) is a particularly useful tool in the search for genetic contributions to glaucoma. Recently, chromosome 9p21 has become a major focus of research endeavour, with multiple genome‐wide association studies suggesting associations to POAG . Herein, we provide a review of the chromosome 9p21 susceptibility locus as a risk factor for POAG .