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Association of single‐nucleotide polymorphism rs4236601 near caveolin 1 and 2 with primary open‐angle glaucoma: a meta‐analysis
Author(s) -
Huang Wenbin,
Wang Wei,
Zhou Minwen,
Zhang Xiulan
Publication year - 2014
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12201
Subject(s) - medicine , meta analysis , odds ratio , confidence interval , publication bias , funnel plot , open angle glaucoma , glaucoma , single nucleotide polymorphism , ophthalmology , gastroenterology , genotype , genetics , biology , gene
Background To clarify the effects of a single‐nucleotide polymorphism, rs4236601[ A ] near caveolin 1 and 2, on primary open‐angle glaucoma ( POAG ) risk. Design Meta‐analysis. Participants A total of 5774 patients and 40 598 controls from previously reported case–control studies were included. Methods A comprehensive literature search was performed for studies published up to A pril 2013. Summary odds ratios ( OR s) and 95% confidence intervals ( CI ) were calculated, employing random‐ or fixed‐effects models according to between‐study heterogeneity. Publication bias of the literature articles was evaluated using funnel plots and E gger's test. Main Outcome Measures OR for the effects of rs4236601[ A ] on POAG risk. Results Five eligible studies were included in this meta‐analysis. Overall, the association between rs4236601[ A ] and risk for POAG was statistically significant ( OR = 1.23, 95% CI 1.12–1.34; P < 0.001). Stratified analyses showed that the association between rs4236601[ A ] and POAG risk was statistically significant in C aucasians ( OR = 1.25, 95% CI 1.18–1.33; P < 0.001) and A sians ( OR = 3.33, 95% CI 1.56–7.08; P = 0.003) but not in A fricans. Increased risks were found in age‐ and sex‐matched studies ( OR = 1.26, 95% CI 1.14–1.40; P < 0.001), but no statistically significant risk was found in unmatched studies. Conclusions This meta‐analysis suggests that rs4236601[ A ] is associated with increased risk for POAG in C aucasian and A sian populations. However, well‐designed gene–environment interaction studies and studies including more ethnic groups are required in further investigations.