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Ibopamine challenge test can be used to differentiate glaucoma suspects from glaucoma patients
Author(s) -
Ullrich Katja,
Craig Jamie E,
Landers John
Publication year - 2013
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12200
Subject(s) - medicine , glaucoma , intraocular pressure , ophthalmology , trabecular meshwork , open angle glaucoma
Background Many countries face the challenge of a rising number of patients with or at risk of developing glaucoma. A test to differentiate between people who are unlikely to develop glaucoma and those at risk for the disease could be clinically useful. Ibopamine, when administered topically, temporarily increases aqueous production. Normal eyes with healthy trabecular meshwork show no significant change in intraocular pressure ( IOP ) following an ibopamine challenge; however, those with glaucoma demonstrate elevated IOP . Design The study was designed as a prospective case–control study in a tertiary hospital. Participants Patients were recruited consecutively as they presented to glaucoma clinics at F linders M edical C entre ( n = 39); the sample included 18 glaucoma suspects and 21 patients with glaucoma. All patients had open anterior chamber angles and no evidence of secondary glaucoma. Methods Patients underwent IOP measurements followed by instillation of ibopamine 2% solution and subsequent repeated IOP assessment. The difference between the baseline measurement and that taken at 45 min was determined and compared between groups. Main Outcome Measure The outcome measure was the positivity of the ibopamine challenge test, defined by an increase in IOP > 3 mmHg. Results We observed a mean increase in IOP of 1.9 ± 1.6 mmHg or 12.5 ± 10.3%) for glaucoma suspects and 7.4 ± 4 mmHg or 52.4 ± 26.5% for glaucoma patients ( P < 0.0001). Four glaucoma suspects (22%) and 19 glaucoma patients (90%) tested positive ( P < 0.0001). Conclusion This study demonstrates that ibopamine has potential as a test to differentiate glaucoma suspects from patients with glaucoma.